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Year : 2022  |  Volume : 16  |  Issue : 1  |  Page : 19-23

Cytokeratins: A potential biomarker among smokers – An observational study in Indian population

Department of Periodontology, Army Dental Centre (Research and Referral), New Delhi, India

Correspondence Address:
Parvez Hasib Shaikh
Department of Periodontology, Army Dental Centre (Research and Referral), New Delhi
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/jodd.jodd_2_21

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Introduction: Gingival epithelium is made up of stratified squamous epithelium consisting of specific cytokeratins (CKs), as intermediate filament proteins of the cytoskeleton. These CKs are involved in transduction signals and transport of nutrients from inside to outside the cell and vice versa. Their expression varies in diseased and inflammatory conditions and can serve as prognostic markers in various diseases. Objectives: The objective of the study is to evaluate the alteration of CK pattern and topographical distribution of individual CK among smokers and nonsmokers of Indian population. Subjects and Methods: Gingival tissue samples from smokers and nonsmokers were obtained after taking their consent and segregated as healthy and inflamed into four groups depending on probing depth, clinical attachment loss, and bleeding on probing based on well-defined inclusion criteria such as young, systemically healthy participants and exclusion criteria such as old edentulous patients suffering from systemic disease. Each tissue sample was blinded and subjected for histopathological and immunohistochemical analysis. Results: Immunohistochemical analysis for CKs CK19, CK8, and CK18 for their pattern and topographical distribution in gingival tissues were obtained using specific antibodies. Histopathological examination was done to study aberration in tissue morphology. Conclusions: Data were collated from all the groups and CK was analyzed for decreased or increased expression, topographical distribution, in various cell layers, and association with other diseases among Indian population was evaluated.

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