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Year : 2021  |  Volume : 15  |  Issue : 1  |  Page : 97-98

Well begun is half done! Substantial progress toward whole-tooth regeneration

1 Department of Periodontology, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh, India
2 Department of Orthodontics and Dentofacial Orthopaedics, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh, India

Date of Submission04-Sep-2020
Date of Acceptance17-Sep-2020
Date of Web Publication09-Mar-2021

Correspondence Address:
Deepak Sharma
Department of Periodontology, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/JODD.JODD_57_20

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How to cite this article:
Masood S, Sharma D, Negi N. Well begun is half done! Substantial progress toward whole-tooth regeneration. J Dent Def Sect. 2021;15:97-8

How to cite this URL:
Masood S, Sharma D, Negi N. Well begun is half done! Substantial progress toward whole-tooth regeneration. J Dent Def Sect. [serial online] 2021 [cited 2021 Apr 18];15:97-8. Available from: http://www.journaldds.org/text.asp?2021/15/1/97/310968

Dear Editor,

Human teeth have limited capacity to regenerate and thus the repair of the damaged dental tissues remains challenging. Tooth loss can lead to physical and mental suffering that compromises self-esteem and quality of life. The role of teeth in oral functions, including mastication, swallowing, and pronunciation, is indispensable for adequate general health, social activity, and quality of life.[1] The current methods of dental rehabilitation include removable or fixed-tooth or implant-supported prosthesis. Even though these approaches have a significant success rates, the associated speech difficulty, altered sensory experience with food, biological, mechanical and esthetic complications remain major issues.[2]

The tooth comprises of complex hard tissue namely enamel, dentin, cementum, and soft tissues namely pulp and periodontal ligaments, including peripheral nerve fibers and blood vessels. Human odontogenesis originates from the oral epithelium and is regulated by reciprocal epithelial–mesenchymal interactions in the developing embryo.[3],[4] Substantial advances in the development of regenerative therapies have been driven by our understanding of embryonic development, stem cell biology, and tissue engineering technologies.[5]

Whole-tooth regeneration is considered to be an attractive concept for next-generation regenerative therapy as a form of bioengineered organ replacement. Toward the end of the 20th century, several studies have been conducted utilizing the different approaches for whole-tooth regeneration. The researchers have achieved considerable success with innovative approaches utilizing organ germ culture method, stem cells, and technique of cell homing and decellularized tooth buds to regenerate whole tooth in different in in vitro, ex vivo, or in vivo models. The regenerated teeth have shown comparable physical, mechanical, eruption, and sensory properties to natural teeth. The important studies are summarized in [Table 1].[6],[7],[8],[9],[10],[11],[12],[13] Bioengineered tooth through organ germ method is the most commonly used experimental approach. This involves compartmentalization of epithelial and mesenchymal cells at a high cell density to mimic multicellular assembly conditions and epithelial–mesenchymal interactions in organogenesis.[6],[7],[8]
Table 1: Various experimental approaches used for whole-tooth regeneration

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Research in the characterization of stem/progenitor cells in dental tissues and their manipulation and development of tissue engineering scaffold materials bring closer the goal of making tooth tissue regeneration a clinically relevant practice. One of the fundamental issues in whole-tooth regeneration is to devise approaches that are economically viable, are practically possible, and can translate into clinical treatments for patients who cannot afford or are contraindicated for dental implants.[6],[7],[8],[9],[10],[11],[12],[13]

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Conflicts of interest

There are no conflicts of interest.

  References Top

Proffit WR, Fields HW Jr., Sarver DM. Contemporary Orthodontics. St. Louis: Mosby Press; 2004. p. 78-83.  Back to cited text no. 1
Pjetursson BE, Brägger U, Lang NP, Zwahlen M. Comparison of survival and complication rates of tooth-supported fixed dental prostheses (FDPs) and implant-supported FDPs and single crowns (SCs). Clin Oral Implants Res 2007;18 Suppl 3:97-113.  Back to cited text no. 2
Oshima M, Tsuji T. Functional tooth regenerative therapy: Tooth tissue regeneration and whole-tooth replacement. Odontology 2014;102:123-36.  Back to cited text no. 3
Tucker A, Sharpe P. The cutting-edge of mammalian development; how the embryo makes teeth. Nat Rev Genet 2004;5:499-508.  Back to cited text no. 4
Nakao K, Tsuji T. Dental regenerative therapy: Stem cell transplantation and bioengineered tooth replacement. Jpn Dent Sci Rev 2008;44:70-5.  Back to cited text no. 5
Nakao K, Morita R, Saji Y, Ishida K, Tomita Y, Ogawa M, et al. The development of a bioengineered organ germ method. Nat Methods 2007;4:227-30.  Back to cited text no. 6
Ikeda E, Morita R, Nakao K, Ishida K, Nakamura T, Takano-Yamamoto T, et al. Fully functional bioengineered tooth replacement as an organ replacement therapy. Proc Natl Acad Sci U S A 2009;106:13475-80.  Back to cited text no. 7
Mine A, Hayano S, Fukumoto S, Kasugai S, Yamaguchi A, Tsuji T, Kuboki T. Practical whole-tooth restoration utilizing autologous bioengineered tooth germ transplantation in a postnatal canine model. Sci Rep 2017;7:44522.  Back to cited text no. 8
Kim K, Lee CH, Kim BK, Mao JJ. Anatomically shaped tooth and periodontal regeneration by cell homing. J Dent Res 2010;89:842-7.  Back to cited text no. 9
Wu Z, Wang F, Fan Z, Wu T, He J, Wang J, et al. Whole-tooth regeneration by allogeneic cell reassociation in pig jawbone. Tissue Eng Part A 2019;25:1202-12.  Back to cited text no. 10
Duailibi SE, Duailibi MT, Zhang W, Asrican R, Vacanti JP, Yelick PC. Bioengineered dental tissues grown in the rat jaw. J Dent Res 2008;87:745-50.  Back to cited text no. 11
Ohazama A, Modino SA, Miletich I, Sharpe PT. Stem-cell-based tissue engineering of murine teeth. J Dent Res 2004;83:518-22.  Back to cited text no. 12
Zhang W, Vazquez B, Oreadi D, Yelick PC. Decellularized Tooth Bud Scaffolds for Tooth Regeneration. J Dent Res 2017;96:516-23.  Back to cited text no. 13


  [Table 1]


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