|LETTER TO EDITOR
|Year : 2021 | Volume
| Issue : 1 | Page : 97-98
Well begun is half done! Substantial progress toward whole-tooth regeneration
Saniya Masood1, Deepak Sharma1, Nishant Negi2
1 Department of Periodontology, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh, India
2 Department of Orthodontics and Dentofacial Orthopaedics, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh, India
|Date of Submission||04-Sep-2020|
|Date of Acceptance||17-Sep-2020|
|Date of Web Publication||09-Mar-2021|
Department of Periodontology, H. P. Government Dental College and Hospital, Shimla, Himachal Pradesh
Source of Support: None, Conflict of Interest: None
|How to cite this article:|
Masood S, Sharma D, Negi N. Well begun is half done! Substantial progress toward whole-tooth regeneration. J Dent Def Sect. 2021;15:97-8
Human teeth have limited capacity to regenerate and thus the repair of the damaged dental tissues remains challenging. Tooth loss can lead to physical and mental suffering that compromises self-esteem and quality of life. The role of teeth in oral functions, including mastication, swallowing, and pronunciation, is indispensable for adequate general health, social activity, and quality of life. The current methods of dental rehabilitation include removable or fixed-tooth or implant-supported prosthesis. Even though these approaches have a significant success rates, the associated speech difficulty, altered sensory experience with food, biological, mechanical and esthetic complications remain major issues.
The tooth comprises of complex hard tissue namely enamel, dentin, cementum, and soft tissues namely pulp and periodontal ligaments, including peripheral nerve fibers and blood vessels. Human odontogenesis originates from the oral epithelium and is regulated by reciprocal epithelial–mesenchymal interactions in the developing embryo., Substantial advances in the development of regenerative therapies have been driven by our understanding of embryonic development, stem cell biology, and tissue engineering technologies.
Whole-tooth regeneration is considered to be an attractive concept for next-generation regenerative therapy as a form of bioengineered organ replacement. Toward the end of the 20th century, several studies have been conducted utilizing the different approaches for whole-tooth regeneration. The researchers have achieved considerable success with innovative approaches utilizing organ germ culture method, stem cells, and technique of cell homing and decellularized tooth buds to regenerate whole tooth in different in in vitro, ex vivo, or in vivo models. The regenerated teeth have shown comparable physical, mechanical, eruption, and sensory properties to natural teeth. The important studies are summarized in [Table 1].,,,,,,, Bioengineered tooth through organ germ method is the most commonly used experimental approach. This involves compartmentalization of epithelial and mesenchymal cells at a high cell density to mimic multicellular assembly conditions and epithelial–mesenchymal interactions in organogenesis.,,
|Table 1: Various experimental approaches used for whole-tooth regeneration|
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Research in the characterization of stem/progenitor cells in dental tissues and their manipulation and development of tissue engineering scaffold materials bring closer the goal of making tooth tissue regeneration a clinically relevant practice. One of the fundamental issues in whole-tooth regeneration is to devise approaches that are economically viable, are practically possible, and can translate into clinical treatments for patients who cannot afford or are contraindicated for dental implants.,,,,,,,
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Conflicts of interest
There are no conflicts of interest.
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